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NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients.
Xu Q, Qiu X, Jiao Z, Zhang M, Chen J, Zhong M. Xu Q, et al. Pharmacogenomics. 2017 Mar;18(4):381-392. doi: 10.2217/pgs-2016-0171. Epub 2017 Feb 17. Pharmacogenomics. 2017. PMID: 28244807
AIM: To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) on cyclosporine (CsA) efficacy in renal transplant recipients. ...CONCLUSION: Detecting NF …
AIM: To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of activated T-cells (NFATs) pathway genes (PPIA, PP …
Calcineurin inhibitors regulate fibroblast growth factor 23 (FGF23) synthesis.
Bär L, Großmann C, Gekle M, Föller M. Bär L, et al. Naunyn Schmiedebergs Arch Pharmacol. 2017 Nov;390(11):1117-1123. doi: 10.1007/s00210-017-1411-2. Epub 2017 Jul 31. Naunyn Schmiedebergs Arch Pharmacol. 2017. PMID: 28761977
Calcineurin as well as NFAT expression were quantified by RT-PCR in UMR106 cells. UMR106 cells expressed calcineurin subunits Ppp3r1, Ppp3ca, Ppp3cb, and Ppp3cc as well as NFATc1, NFATc3, and NFATc4. ...
Calcineurin as well as NFAT expression were quantified by RT-PCR in UMR106 cells. UMR106 cells expressed calcineurin subunits Ppp3r1, …
A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
Rodríguez A, Roy J, Martínez-Martínez S, López-Maderuelo MD, Niño-Moreno P, Ortí L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM. Rodríguez A, et al. Mol Cell. 2009 Mar 13;33(5):616-26. doi: 10.1016/j.molcel.2009.01.030. Mol Cell. 2009. PMID: 19285944 Free PMC article.
Mutations in this region disrupt binding of mammalian calcineurin to NFATC1 and the interaction of yeast calcineurin with substrates including Rcn1, which contains an LxVP motif. ...
Mutations in this region disrupt binding of mammalian calcineurin to NFATC1 and the interaction of yeast calcineurin with substrates …